They researched risk factors likely to be of general concern to orthopaedic surgeons and pooled data to identify 45 variables of interest. The researchers found a nonunion rate of 4.93% overall with substantial variation from bone to bone. The lowest nonunion bone rates were in metacarpal at 1.47% and radius at 2.10%. The highest nonunion rates were in scaphoid at 15.46%, tibia+fibula at 13.95%, and femur at 13.86%. The presence of other diseases boosted risk. Osteoarthritis, rheumatoid arthritis, and diabetes increased the odds of nonunion by at least 40%. Use of certain medications such as analgesics also upped risk. Other medications were protective. Antidiabetic medications, other than insulin, and oral contraceptives are inversely associated with nonunion. Nonunion odds were significantly increased by many risk factors including the number of fractures, use of prescription analgesics (NSAIDs+opioids), operative treatment, open fracture, anticoagulant use, osteoarthritis with or without rheumatoid arthritis, anticonvulsant use with or without benzodiazepine, opioid use, diabetes, high-energy injury, osteoporosis, male gender, insulin use, smoking, obesity, antibiotic use, Vitamin D deficiency, diuretic use and kidney insufficiency.
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The Offering is expected to close on or about October 13, 2016 , subject to satisfaction of customary closing conditions Concordia intends to use the net proceeds from the Offering for general corporate purposes, including funding of pipeline products and funding small regional product acquisitions The Notes are being offered and sold in the United States to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the “Securities Act”), and to certain non-U.S. persons, including persons resident in Canada , in accordance with Regulation S under the Securities Act and other applicable securities laws. The Notes will not be registered under the Securities Act or the securities laws of any state or any other jurisdiction and may not be offered or sold in the United States absent an effective registration statement or an applicable exemption from the registration requirements under the Securities Act and applicable state securities laws and foreign securities laws. Any offer or sale of the Notes in Canada will be made on a private placement basis in a manner that is exempt from the prospectus requirements of applicable Canadian securities laws. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sales of the Notes in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. This notice is being issued pursuant to and in accordance with Rule 135(c) under the Securities Act. About Concordia Concordia is a diverse, international specialty pharmaceutical company focused on generic and legacy pharmaceutical products and orphan drugs. The Company has an international footprint with sales in more than 100 countries, and has a diversified portfolio of more than 200 established, off-patent molecules that make up more than 1,300 SKUs. Concordia also markets orphan drugs through its Orphan Drugs Division, consisting of Photofrin for the treatment of certain rare forms of cancer, which is currently undergoing testing for potential new indications. Concordia operates out of facilities in Oakville, Ontario and, through its subsidiaries, operates out of facilities in Bridgetown, Barbados ; London, England and Mumbai, India . http://ur.my/consultantinterviewcourse65164Notice regarding forward-looking statements: This press release includes forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995 and forward-looking information within the meaning of Canadian securities laws, regarding Concordia and its business, which may include, but are not limited to, the use of proceeds of the Offering, the completion of the Offering and timing thereof, the anticipated number of product launches, acquisition opportunities and the funding of such acquisitions and other factors.
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